Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
نویسندگان
چکیده
S.A.L. designed and supervised all experiments and prepared the manuscript. Y.W. and J.W.L. performed chemical synthesis of aminoadamantane nitrates, analysis of the structure-activity relationship, and hit-to-lead optimization. H.T., P.X., M.T., T. T, J.P.-C., K.B. and D.Z. performed or analyzed electrophysiological experiments. J.C. and S.S. performed the surgery for the animal model of cerebral ischemia with assistance of W.L. T.N. performed the pharmacodynamic assay showing S-nitrosylation of the NMDA receptor with assistance of E.H. S.R.M. and N.N. helped analyze data, performed statistical analysis, prepared figures, and assisted in experiments. S.A.L. and S.R.M. wrote the manuscript, and all coauthors participated in editing the manuscript.
منابع مشابه
Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
Stroke and vascular dementia are leading causes of morbidity and mortality. Neuroprotective therapies have been proposed but none have proven clinically tolerated and effective. While overstimulation of N-methyl-d-aspartate-type glutamate receptors (NMDARs) is thought to contribute to cerebrovascular insults, the importance of NMDARs in physiological function has made this target, at least in t...
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2016